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Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation

The injections are usually given frequently at the start of treatment

Assessment Clinical judgement is required when selecting an injection site and needle length

Groups 9 and 10 (referencereference): Colitis was induced and the rats treated with dexamethasone (1 mg/kg, i.p.) or mesalazine (150 mg/kg, p.o.) for 5 days started 2 h before UC induction