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Specifically to Treg, systemic administration can limit Treg accumulation in pathologic sites of inflammation within the skin (e.g., the epidermis) due to minimal expression of skin-homing receptors on the migrating Treg (155, 156)

b , Gene Ontology analysis of the MS-identified proteins that specifically interacted with INTS12-WT after UV irradiation

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doi: 10.1056/NEJM200507073530117 8