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10.1074/jbc.M506096200 46

Although it is hard to ascertain the cause of pyroglutamic acidosis because most of the reported patients had multiple medical comorbidities and/or kidney dysfunction or kidney failure, all of the patients were using APAP

The glutathione precursor N-acetylcysteine improves immune function in postmenopausal women

The target proteins for VPA, namely MTOR (PDB ID: 4JT5), PTGS2 (PDB ID: 5KIR), TLR4 (PDB ID: 4G8A) and CBZ namely EGFR (PDB ID: 7KXZ), GSK3B (PDB ID: 5KPL), STAT3 (PDB ID: 6NJS) were retrieved from the RCSB Protein Data Bank