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Smith MA, Newton LP, Blanch MAB, Cuervo-Pardo L, Cho L, Newton D, Wang X, Li M, Lang DM (2020) Risk for anaphylactic reaction from cardiac catheterization in patients receiving beta-adrenergic blockers or angiotensin-converting enzyme-inhibitors

FDA also cited serious adverse events, including death, in a study where Ipamorelin was administered intravenously for improving gastric motility

In REDEFINE 1, adverse events were mainly gastrointestinal (79.6% in the CagriSema group vs 39.9% with placebo) including nausea (55% vs 12.6%), constipation (30.7% vs 11.6%), and vomiting (26.1% vs 4.1%)

Oral use of the antifungal ketoconazole has been associated with hepatic toxicity, including some fatalities