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& Leppla, S

Interestingly, using whole-cell patch clamp it was shown that TRPM3 channel activity, when modulated with the TRPM3-agonist pregnenolone sulphate, is restored in IL-2 stimulated NK cells of ME/CFS donors following 24-h incubation with NTX [199]

The inconsistent outcomes of different studies could be attributed to the type of detected biospecimens (for example, CSF versus plasma), and the types of investigated populations (i.e., ethnic background heterogeneity)