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Author contributions D-DW, S-MH, and Y-MW conceived and designed the study

A small portion of cellular glutathione is in the oxidized state (GSSG), which takes on the form of a dimer connected by a disulfide bond between the cysteines of two glutathione molecules

Coenzyme Q10 is commonly supplemented at doses between 100 mg and 300 mg daily , though some individuals, particularly those with heart failure or taking statins, may use higher doses under medical supervision

The addition of L-aspartic acid or L-glutamic acid with L-citrulline and arginirosuccinic acid synthase as the rate determining enzyme forms L-arginine [188]