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Finally, the advanced glycation end products-receptor (AGE-RAGE) signaling pathway is involved in multiple downstream processes, such as angiogenesis, inflammation, cellular proliferation, osteogenesis, and so on

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Erastin can mediate ferroptosis through mitochondrial voltage-gated anion channels (VDAC) and xCT, which impairs VDAC function, thereby resulting in mitochondrial dysfunction, ROS production, and cell death [120]

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