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GLP-1 receptor agonists have earned their place as a clinically credible intervention for metabolic PMOS

621 In melanoma, genome-wide hypomethylation induces the upregulation of PD-L1 and the secretion of inhibitory cytokines, concomitant with EMT alterations that collectively foster an immunosuppressive microenvironment

ILCs, which lack T cell receptor (TCR) expression, are innate counterparts of T cells involved in host defense against infection, metabolic homeostasis, tissue repair, and chronic inflammatory diseases by secreting effector cytokines and regulating the functions of other innate and adaptive immune cells (6466)

Healthcare professionals should educate patients on these dangers and discourage them from purchasing or using compounded semaglutide