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Ethanol has been shown to disrupt LTP in different brain regions, including the hippocampus, a region critically involved in memory formation and emotional regulation (Yao et al

Estrogen plays a significant role in regulating glucose and fat metabolism by enhancing insulin sensitivity, promoting glucose uptake in peripheral tissues, and influencing lipid profiles 84

Therefore, the development of drugs that target common points of these crosstalk pathways is a novel approach to antagonize cisplatin-induced ototoxicity without affecting antineoplastic efficacy