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Important Discontinuation Instructions In order to avoid developing withdrawal symptoms, instruct patients not to discontinue Hydrocodone Bitartrate and Acetaminophen Tablets without first discussing a tapering plan with the prescriber [see DOSAGE AND ADMINISTRATION] Maximum Daily Dose of Acetaminophen Inform patients not to take more than 4,000 milligrams of acetaminophen per day

Small interfering RNA transfection Cells were transfected with Lipofectamine RNAiMAX (Invitrogen) as transfection reagent, together with 20 nM of the corresponding siRNA for 72 h, following the manufacturers instructions

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Here are some strategies you can use: Stay hydrated: Drink plenty of water to keep your mouth and hands busy and flush out nicotine toxins