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Such a separation is vital given that augmented effectiveness could result from various actions: (i) pharmacodynamically complementarity with donepezil increasing cholinergic transmission and Nar-NP attenuating oxidative/inflammatory damage and regulating GABAergic/GSK-3 signaling, (ii) shared downstream effectswherein both agents meet in some antioxidant or anti-inflammatory pathway to give additive control of neurotoxicity, or (iii) pharmacokinetic permissivenesswith nanoparticle delivery modifying naringenin bioavailability or distribution that may incidentally impact donepezil clearance