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12 mM K 2 HPO 4 , 6.6 mM KH 2 PO 4 , 1.52 mM (NH 4 ) 2 SO 4 , 0.34 mM Na-citrate*2H 2 O, 1 mM MgSO 4

TABLE 1 List of key bridging factors regulating both autophagy and Nrf2 pathway

Data sets were generated from at least three independent experiments

Jos Esprito Santo, Lote 49, Loja 1, Chelas, 1900-672 LISBOA, PORTUGAL Telephone: + 351-218371699 Fax: + 351-218371712 E-mail: [email protected] Acknowledgements This article is based on a paper presented at the International Conference on Chromosome 21 and Medical Research on Down Syndrome, Barcelona, 1997