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While this might suggest a temporal association between BMAL1 driven transcription/translation of NRF2, we cannot be certain since BMAL1 and CLOCK can each separately bind to other proteins (40, 47) and NRF2 can transcribe genes involved in xenobiotic disposition, protection from electrophiles and general stress response (48, 49)

Additionally, SIRT6 deficiency results in VSMC senescence due to hyperacetylation at H3K9 and H3K27, ultimately causing DNA telomere damage

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This can result in reduced production of stomach acid and intrinsic factors, which are both essential for the absorption of vitamin B12