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2 Erythrocytes are particularly vulnerable to oxidative stressors due to their role in oxygen transport, thus acute hemolytic anemia is the main associated pathology

If distinct signatures do exist, and have adaptive function, then they should likely be produced in response to the same environmental stimuli as those that produce analogous facial expressions, and it should in time be possible to describe them in terms of their distinct signatures of volatile organic compounds

Better screening for anemia and infectious diseases, and modified harm reduction strategy for injection drug users are primary needs in HIV patients

Ethics declarations Conflict of Interest The authors declare no conflicts of interest relevant to this manuscript