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32 However, the detailed mechanism regarding how glutathione depletion leads to inhibition of the NF-kB signaling pathway remains largely uncharacterized

Mitochondrial dynamics are altered too: excessive fission (fragmentation) of mitochondria in neurons and microglia is noted after surgery, which is usually a sign of stress and often precedes cell death (187, 188)

Additionally, according to a prior study, the antioxidant glutathione (GSH) content in cells was lowered and cytosolic peroxide was elevated following MTX treatment (Kesik et al