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Putra et al., 2016

17(Suppl 1): i55-i56

A 2012 Cochrane Review of pooled data from three trials examining tracheostomy-free survival in 974 patients treated with riluzole and 503 placebo-treated patients demonstrated a statistically significant increase in survival from 11.8 months to 14.8 months, but without any benefit on measures of muscle strength

Thus, the timing of DSB induction and repair relative to the first S-phase and the first mitosis is intrinsically limiting to preventing mosaicism and maintaining genome stability in embryonic gene editing