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The comparatively higher sample size addresses biological variability, possible attrition and death rates (e.g., Doxorubicin toxicity), and type I error inflation in pairwise comparisons (Tukeys post-hoc test)

Sometimes they have too few ingredients to justify their costs, or they include way too many ingredients at doses significantly lower than those used in successful research

[DOI] [PubMed] [Google Scholar] 90.Sever A.Z., Sever M., Vidovic T., Lojo N., Kolenc D., Vuletic L.B., Drmic D., Kokot A., Zoricic I., Coric M., et al

A review of a bi-layered living cell treatment (Apligraf) in the treatment of venous leg ulcers and diabetic foot ulcers