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[DOI] [PubMed] [Google Scholar] 44.Yang BK, Vivas EX, Reiter CD, Gladwin MT

However, a prolonged half-life of more than 4 h can occur in individuals that either consume an overdose of APAP or that exhibit a clinical history of hepatic injury or chronic liver disease ( As APAP hepatotoxicity is the most common cause of acute liver failure requiring liver transplantation, a better understanding of the molecular events contributing to APAP hepatotoxicity may provide novel opportunities for intervention

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Together, these data and other findings suggest that if NMN treatment leads to increased carbonyl reductase activity, this does not translate into an increased risk of cardiac dysfunction