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With regard to the increased secretion of EVs during the progression of NAFLD, experimental studies demonstrated that toxic lipids significantly increase the production of hepatocyte-derived EVs, which act as mediators of paracrine signaling, causing hepatic stellate cell activation, angiogenesis and activation of macrophages leading to inflammation and chemotaxis [103,104,105]

Fernndez-Real JM, Pearroja G, Castro A, Garca-Bragado F, Hernndez-Aguado I, Ricart W

thus, red blood cells in iron deficiency anemia appear hypochromic (less color) and microcytic (small) under microscopic examination (Urrechaga 2009)

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