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Early report indicated that sensitivity of NBS for CUD was not perfect.29 So, there is a small proportion of clinical CUD cases that might be missed by NBS and will present at the time of metabolic derangement or cardiomyopathy

Local tumor recurrence and cancer progression occurred at a rate of 57.1% and 61.9%, respectively, in the control group, with corresponding rates of 4.5% and 9.1% in the FWGE group