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Week 48 Consistent cognitive improvements

Most patients see significant improvement after 36 treatments spaced a few weeks apart, followed by maintenance sessions as needed

It is encoded in the mitochondrial genome and affects insulin sensitivity and cellular metabolism

In addition, in a two-stage, double-blind, randomized, placebo-controlled trial, lixisenatide treatment in early PD participants resulted in slower progression of movement disorders at 12 months than placebo treatment, but the treatment also caused gastrointestinal side effects [168]