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Multiple animal models have been used to study the association between CKD and renal senescence

The review also identified a scarcity of longitudinal incidence data, with only one relevant study reporting a baseline incidence of approximately 8% among individuals aged 4892 years

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The process of pyroptosis mainly involves the caspase-1-dependent pathway (classical pathway) and the caspase-1-independent pathway (non-classical pathway), and is closely related to the secretion and activation of the pro-inflammatory cytokines interleukin-1 (IL-1) and IL-18, which play an important role in inflammatory response and immune defense through the release of inflammatory mediators and the recruitment of immune cells (103105)