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Interestingly, in fibrils composed of mutant -syn, this buffering capacity was reduced (Ryan et al., 2018)

Raps, M., Kleider, C

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The current state of knowledge cannot answer questions such as the threshold level of oxidative stress necessary to activate tumor development, the types of ROS that promote tumorigenic/antitumorigenic signaling, critical subcellular localizations where oxidative stress peaks, and other factors