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In addition, the glutaminase inhibitor IPN60090 can be combined with CB839 in the treatment of Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML), and with increasing doses of CB839 and IPN60090, the levels of intracellular NADPH and NADP+ are reduced, thereby inhibiting the proliferation of MDS and AML cells [72]

Compared to ethanol fixated cells, no decrease in fluorescence signal was visible for the settings used in the isASO-ID protocol, indicating sufficient lysine availability for biotinylation

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Results showed good stability of the complex across indicators such as RMSD, RMSF, SASA, and radius of gyration, suggesting that Diosgenin may intervene in ferroptosis and inflammatory injury in RA by binding to and modulating GPX3 function