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The diagnosis of hEDS is given to adults who meet the clinical diagnostic criteria for hEDS

Turner et al

TR EM, PH N ANG MANG THAI V CHO CON B UNG MY VIN DU C OMEGA 3 MI NGY

To bridge the preclinicalclinical gap, three concrete translational pathways are proposed: (1) Biomarker validation: Conduct prospective human cohort studies to verify preclinical biomarkers (e.g., GSDMD-NT for pyroptosis, HMGB1 for inflammation, MDA for lipid peroxidation, ferritin for ferroptosis) in serum and liver biopsies of EHS/CHS patients, establishing their diagnostic (early liver injury detection) and prognostic (MODS progression prediction) utility [59, 89]