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For controlled trials, the comparator could include any non-drug intervention, such as behavioural interventions, placebo, or no support

Javadiyan S, Burdon KP, Whiting MJ, Abhary S, Straga T, et al

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Thus, no single aggregate collection pathway appears essential for aggresome-like organelle formation, and multiple routes likely function in parallel for cargo delivery, consistent with adaptor requirements reported for mammalian models