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The absence or diminished function of ATP7B results in accumulation of copper in the hepatocyte due to both impaired copper excretion into bile and inability to incorporate copper into ceruloplasmin.14 The production of ceruloplasmin without attached copper (apoceruloplasmin), which has a shorter half-life than ceruloplasmin, results in decreased levels of ceruloplasmin in the blood of Wilsons patients

Cancer Lett 250(2):300310 Honey Church J, Alduaij W, Azizyan M, Verbon EH, Post JA, Boonstra J (2012) The influence of reactive oxygen species on cell cycle progression in mammalian cells