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Guidelines for The Diagnosis, Prevention and Management of Cryptococcal Disease in HIV-Infected Adults, Adolescents and Children: Supplement to the 2016 Consolidated Guidelines on the Use of Antiretroviral Drugs for Treating and Preventing HIV Infection (Geneva, Switzerland: World Health Organization)

Interestingly, LPS-binding protein (LBP), an acute phase reactant, can remove LPS by attaching to it tightly, neutralizing its actions, suggesting a therapeutic potential in ME/CFS (Mathison et al., 1992

Option 1: Every Other Night Monday, Wednesday, Friday: Retinol + supporting products Tuesday, Thursday, Saturday: AHA/BHA acids + supporting products Sunday: Recovery night with hydrating products only Option 2: Weekly Cycles Week 1: Focus on exfoliation (acids) Week 2: Focus on anti-aging (retinoids) Repeat cycle Option 3: Seasonal Rotation Winter months: Focus on barrier repair and hydration Summer months: Emphasise protection and oil control Spring/Autumn: Introduce more active treatments The Sandwich Method: Buffering Sensitive Combinations Some ingredients can be used in the same routine if properly buffered with compatible products

Selected Publications Cooper, L.N, Ansari, M.Y., Capshaw, C., Lauer, A.M., Moss, C.F., Sears, K.E