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Both NOX and inducible nitric oxide synthase (iNOS) are vital in generating enhanced ROS levels within phagocytes via oxidative burst to kill invading pathogens ( 2 - produced by NOX is dismutated into H 2 O 2 by superoxide dismutase1 (SOD1), whereas nitric oxide produced by inducible nitric oxide synthase (iNOS) reacts with O 2 - resulting in peroxynitrite production ( Mitochondria are considered as the redox-active compartment within the cell, accounting for nearly 90% of oxygen utilization ( 2 -

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These drugs include molecules already approved for human use, such as statins and niacin, and particularly, compounds currently undergoing development such as apolipoprotein A-I mimetics and reconstituted HDL preparations

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