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The PCA was conducted using the FactoMineR package (52) in R, with the first five principal components capturing the primary sources of variation in the data

Upon activation, AMPK promotes the phosphorylation of eNOS at the Ser1177 and/or Ser633 sites, enhances eNOS activity and promotes NO synthesis

Treatment & Results: After intratympanic PRP therapy , the patient reported: A 2030 % reduction in tinnitus intensity Improved hearing thresholds (10 dB+) in low-to-mid frequencies (500 Hz2000 Hz) Enhanced clarity and reduced need for high television volume Follow-up audiograms continue to show sustained improvements

49 Loss of podocytes remains a critical factor in glomerulosclerosis, a hallmark of DKD progression 41 (Fig