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Comprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of glioblastoma

Liu YA, Zeng LL, Chen Y, et al

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The crystal structure of human GPx3 revealed that each subunit contained a selenocysteine (Sec) residue and the active Sec-53 was located in a pocket on the protein surface with Gln-87, Trp-161 and Asn-162 nearby 13 , which formed a catalytic tetrad highly conserved in the selenium-dependent GPx family 14