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Cancer cells also need to keep ROS production under control, and glutamine converted in glutamate serves the synthesis of glutathione peroxidase as a major anti-oxidative enzyme from glutamine

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In-depth mechanistic studies revealed that ES penetrates the cell membrane by forming a complex with extracellular Cu2+, reducing Cu2+ to Cu+, and releasing highly reactive ROS in the mitochondria

Imaging techniques (i.e., ERCP) have also shown biliary tract calculi in many patients with established PSC, suggesting the removal of calculi as an exclusionary criterion (Kaw et al, 1995)