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The mechanism of Riluzole effects in the treatment of ALS remains to be elucidated and may be related to the inhibition of glutamate release, the reduction of neuronal toxicity response, the stabilization of neuronal membranes and the blockade of voltage-sensitive sodium channels (11) to reduce the neuronal excitability

Itraconazole and fluconazole, though less extensively studied in children, appeared effective alternatives for both species, but their use requires caution due to potential hepatotoxicity and other adverse effects

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Daily administration is common in rodent studies but may not be necessary for all research objectives given Dihexa's prolonged downstream effects on synaptic density that persist well beyond plasma clearance