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however, larger, controlled clinical trials are necessary to validate these findings and establish standardized treatment protocols

1 Introduction The unprecedented pace of industrialization and urbanization over recent decades has introduced a vast array of chemical contaminants into our environment, among which environmental endocrine disruptors (EEDs) have emerged as a particularly concerning threat to human reproductive health ( 1.1 Sources and classification of EEDs Environmental endocrine disruptors encompass a remarkably diverse array of chemical compounds that can be systematically categorized into three distinct groups based on their origin, chemical properties, and environmental behavior: Heavy Metals and Metalloids represent one of the most persistent categories of reproductive toxicants

Haider A, Herde AM, Krmer SD, Varisco J, Keller C, Frauenknecht K, et al

Therefore, 1 and 2 were prepared by alkaline hydrolysis of 4 and 5 (Fig