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Altogether, these studies suggest that the beneficial effects of lifestyle interventions on both diabetes and MASLD could be mediated via modulation of the gut microbiota, and as our understanding of the mechanisms involved increases, it may be possible to make targeted therapeutic recommendations (154)

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Indeed, preclinical models have limitations such as the difference of age, with young and health animals employed in the preclinical studies versus the majority of patients in the clinic that are aged and multi-diseased (Talbert et al., 2014