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Digestive disorders are a serious prerequisite for reducing vitamin B12 levels

5.2 The guts role in mediating sleep and redox balance during aging The gastrointestinal tract has long been studied within the context of aging and exhibits multiple hallmarks of physiological decline, including altered microbial colonization, elevated low-grade inflammation, compromised barrier integrity, and reduced absorptive capacity

[DOI] [PMC free article] [PubMed] [Google Scholar] 180.Garcia-Corzo L., Luna-Sanchez M., Doerrier C., Garcia J.A., Guaras A., Acin-Perez R., Bullejos-Peregrin J., Lopez A., Escames G., Enriquez J.A., et al

GHRH analogues and GHRPs act on distinct receptors the GHRH receptor and the GHS-R1a (ghrelin) receptor that converge on the same somatotrophic-axis research model