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We first assessed the expression of REST in different organs and found moderate expression in the heart, liver, spleen, lung, and kidney, as well as lower levels in the brain (Supplemental Figure 1, A and B

That study didnt use 5-Amino-1MQ at all, but its why NNMT became a target worth chasing in the first place

Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia

For instance, Opc is possessed only by the meningococcus, and Opa proteins have different affinities for CEACAM members, with meningococcal Opa primarily targeting CEACAM1 and gonococcal Opa proteins binding to CEACAM1, CEACAM5, CEACAM6, and CEACAM3 on epithelia, neutrophils, and lymphocytes (Sadarangani et al., 2011