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doi: 10.1056/NEJMoa1611925 212 MengZZhouDGaoYZengMWangW

This study delves into the interactions between specific subtypes of cDCs and UC through scRNA-seq, identifying LAMP3 + cDC3s as a key cell subset for the response to TNF- inhibitors and dynamic alterations in cDC3s with unique transcriptomes

Switching is possible but not straightforward

Moreover, astrocytes in AD often exhibit impaired phagocytic capacity and defective immune clearance, resulting in the accumulation of neuronal debris and secondary iron release, further exacerbating local cytotoxicity and iron dyshomeostasis (Zeng et al., 2025)