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In addition to its roles in immune regulatory function and epithelial barrier defects, IFN- has been shown to contribute to vascular leakage, all of which sustain and perpetuate inflammation in the context of IBD ( OMVsRecruitment of Caspase-5 and Links to Barrier Dysfunction

Since these hormones also decrease with age, boosting growth hormone without balancing sex hormones may have little effect

Glucose also plays a key role, as it enters cells through GLUT1 and GLUT4, with insulin enhancing glucose uptake by promoting GLUT4 translocation to the cell membrane

doi: 10.1016/j.intimp.2023.110651 31 CaiJChenZYangXCaiJWChenLChenSet al