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Co-enzyme B12 also interacts with the enzyme methionine synthase (5-methyltetrahydrofolate-homocysteine methyltransferase), required for the conversion of homocysteine to methionine, which is essential for folic acid metabolism and the formation of thymine, which is a component of DNA

Certain medications, such as proton pump inhibitors and metformin, can deplete vitamin B12 in the body and lead to an increased requirement

The annual and 5-year budget impact of converting patients in both cohorts to oral supplement therapy is presented in Table 4

This is especially important if you dont have a reliable source of vitamin B12 in your diet, or tend to forget to take your supplements