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Kruglikov and Scherer 49 proposed that lipedema reflects a pseudopregnancy state of gluteofemoral white adipose tissue, characterized by heightened sensitivity to lipopolysaccharides and complement dysfunction, leading to low-grade inflammation and adipose expansion

Primary outcomes were feasibility (assessed via patient feedback and retention rate, accuracy and ease of remote LFI measurement), adherence to the exercise regimen (classified as adherent, partially adherent or non-adherent if patients attempted 75%, 50-75% or 0.05)

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