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Nitrogen as the drift gas was held at a flow rate of 90 mL/min in the IMS cell with a wave velocity of 600 m/s and a wave height of 40 V

Recent research has taken advantage of the neuroprotective properties of indole-containing compounds such as melatonin, which is reduced in AD patients (Rossotti and Rossotti 1965), by combining the indole structure with other bioactive components (e.g., 8-hydroxyquinolines and tacrine) to create compounds with multiple therapeutic benefits aimed at treating AD (Gans et al

Mosaoa RM, Al-Rabia MW, Asfour HZ, Alhakamy NA, Mansouri RA, El-Agamy DS, Abdulaal WH, Mohamed GA, Ibrahim SRM, Elshal M (2024) Targeting SIRT1/AMPK/Nrf2/NF-B by sitagliptin protects against oxidative stress-mediated ER stress and inflammation during ANIT-induced cholestatic liver injury

Some of these compounds (for example, verapamil) bind to the Pgp molecule and inhibit in a competitive manner the binding or transport of drugs that are Pgp substrates