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Sleep debt, a consequence of shortened or disordered sleep, or night shift work, is also associated with obesity, insulin resistance and hypertension, raising the possibility that disturbances of normal sleep patterns may have a role in the pathogenesis of the metabolic syndrome

Patients with Mitochondrial Disease:There is an increased risk of valproate-induced acute liver failure and resultant deaths in patients with hereditary neurometabolic syndromes caused by DNA mutations of the mitochondrial DNA Polymerase (POLG) gene (e.g