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These neuronal activation patterns are attenuated or absent in RAMP1/RAMP3 knockout animals, further implicating AMYR and AMYR as the functional receptors mediating these central effects

4.3 Microglia modulation Neuropsychiatric disorders are frequently characterized by increased OS and inflammatory responses, with abnormal activation and dysfunction of microglia playing a significant role (Lehmann et al., 2019)

This lipid accumulation impairs DC-T cell interactions, whereas XBP1 silencing in DCs enhances their antitumor functionality and immunostimulatory dendritic cell activity [84]