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However, larger randomized controlled trials have produced mixed findings, with some reporting no significant cognitive or functional benefit compared with placebo, emphasizing the need for optimized dosing strategies, longer follow-up, and biomarker-guided study designs ( Beyond BBB-bypass strategies such as intranasal delivery, major regulatory milestones in AD have been achieved with anti-amyloid monoclonal antibodies

Prostaglandin E2 impairs P2Y2/P2Y4 receptor signaling in cerebellar astrocytes via EP3 receptors

Industry standards suggest 1-3 times per week initially for 4-8 weeks, though these lack evidence basis

& Vaduganathan, M