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doi: 10.1158/0008-5472.CAN-14-1491 207 VaranasiSKChenDLiuYJohnsonMAMillerCMGangulySet al

Beyond these long-range pathways, intrapulmonary neuronsincluding sensory and adrenergic subtypesexert direct, localized immunomodulatory effects within the lung parenchyma through the release of neuropeptides and neurotransmitters, forming spatially organized neuro-immune units. These units respond not only to local tissue injury and infection but also to inhaled irritants, which can activate sensory nerve terminals and modulate ensuing neuroimmune crosstalk [325, 326]