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10.1007/s00005-017-0480-8 246 SaxtonR

One commenter stated their belief that CMS has statutory authority (section 1848(q)(5)(F) of the Act) and regulatory authority ( 414.1380(c)(2)(i)(A)(2) and 414.1380(c)(2)(i)(A)(9)) to reweight the cost performance category when there are not sufficient measures or flaws in the cost scoring methodology that make it impossible to reliably calculate a score for measures to adequately capture and reflect performance

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Autonomic neuropathy, particularly in ATTRv amyloidosis, disrupts the enteric plexus, leading to loss of inhibitory mechanisms and upregulation of excitatory neurons and subsequently dysmotility symptoms [12, 13]