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According to reports, every 30 s in the world, one diabetic patient suffers from amputation due to persistent diabetic chronic ulcers, and the annual cost of medical costs and lots of productivity due to diabetic wounds is more than 200 billion US dollars (Al-Mohaithef et al., 2022)

Recent progressions in the realms of nanotechnology and gene therapy have unveiled novel pathways for oncological treatment, particularly in augmenting the efficacy of radiotherapeutic interventions 4

Potentiation of invasive activity of hepatoma cells by reactive oxygen species is mediated by autocrine/paracrine loop of hepatocyte growth factor

Such high micromolar GSSG concentrations are unlikely to occur in most subcellular compartments but could be reached in the secretory pathway or during titration experiments of transgenic cell lines with an upregulated GSSG transporter 35,63,64,77