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YL: Writingoriginal draft

Graphical abstract Similar content being viewed by others Introduction Rheumatoid arthritis (RA) is an autoimmune disease characterized by synovitis that can lead to joint deformities [1]

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High-risk NB is characterized by the appearance of this disease after the age of 18 months, the amplification of MYCN (MYCN Proto-Oncogene, BHLH Transcription Factor), or the activation of mechanisms for telomere maintenance (106, 107)