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Preclinical and Clinical Studies with Antioxidants Although evidence of oxidative damage in ALS pathogenesis has been largely described in the literature, all antioxidants tested in patients have so far failed, remaining unclear whether any antioxidant therapies might be effective for treating ALS

This form of programmed cell death also participates in the etiology of several human diseases including cancer, neurodegenerative, and autoimmune disorders

Cells under chronic ferroptotic stress exhibited increased sensitivity not only to the ferroptosis inducer RSL-3 but also to hydrogen peroxide

After its synthesis, GSH is transported to the intracellular compartments, mitochondria, endoplasmic reticulum and nucleus, but most of it is released through transporters toward the extracellular space